Figure 2: Group differences in the global network metrics of structural and functional connectomes.

The bar and error bar represent the mean values and standard deviations of the network properties in each group after removing the effects of age and gender. (A) Significantly reduced strength, global efficiency, local efficiency, clustering and increased shortest path length of SC networks were observed in both CIS and MS patients relative to the controls. (B) Reduced local efficiency and clustering of FC networks in MS patients relative to controls were found. *p < 0.05; **p < 0.01; ***p < 0.005.