Table 1 The demographic information and clinical characteristics of all participants.

From: Disrupted topological organization of structural and functional brain connectomes in clinically isolated syndrome and multiple sclerosis

 

Controls (n = 35)

CIS (n = 41)

MS (n = 32)

F/T/χ2 /Z value

P value

Mean Age (years)

35.0 ± 11.5

35.7 ± 10.7

34.8 ± 8.3

0.08 #

0.92#

Gender (F/M)

23/12

26/15

24/8

1.17â•«

0.56â•«

Mean MMSE

29.1 ± 1.3

27.6 ± 1.4

25.9 ± 1.8

36.44#

<0.001#

Mean PASAT2

46.7 ± 9.2

39.4 ± 7.7

35.4 ± 9.8

14.14#

<0.001#

Mean PASAT3

53.9 ± 6.2

47.5 ± 7.6

41.0 ± 8.7

24.38#

<0.001#

Mean disease duration (months)

–

2.6 ± 2.5

41.8 ± 28.7

8.73*

<0.001*

Mean TWMLL (ml)

–

4.5 ± 10.6

10.3 ± 10.4

2.33*

0.023*

Median EDSS (range)

–

2.0 (0–6)

3.5 (0–6.5)

3.35§

<0.001§

  1. CIS, clinically isolated syndrome; MS, multiple sclerosis; MMSE = Mini-Mental State Examination; PASAT = Paced Auditory Serial Attention Test; EDSS = Expanded Disability Status Scale; TWMLL = Total White Matter Lesion Load. Data are mean ± standard deviation, except for EDSS presented in median (range). #P value and F value were obtained by one-way analysis of variance. *P value and T value were obtained by two-sample t-test. ╫P value and χ2 value were obtained by χ2 test. §P value and Z value were obtained by Wilcoxon rank sum test.
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