Figure 7: PTX3 promotes tumorigenesis and metastasis in vivo.
From: Knockdown of Pentraxin 3 suppresses tumorigenicity and metastasis of human cervical cancer cells
(a) For the xenograft, a total of 5 × 106 control (PBS) and Rh-PTX3 treated mices were injected subcutaneously into the left flank, respectively. Photographs of tumors from mice in each group (n = 5/group) for 16 days. (b) Tumor growth curves were measured after injection, and tumor diameters were measured every 5 days. (c) Mean tumor weight and (d) body weight for each group was calculated at 16 days after injection. (e) Representative images of H&E staining and Ki-67 expression of control and Rh-PTX3 group. (f) Photographs of lungs of the mice from each group were removed and (g) sectioned for evaluation lung metastasis after H&E staining. Representative images of H&E staining of tumor xenografts (magnifications: ×40). (h) There were lung metastatic colonies in the control group significantly fewer than in the Rh-PTX3 group. (i) Average lung weight of the mice from each group were removed and calculated. **P < 0.01.
