Figure 5: Body weights, survival, and histopathological findings of WT and TMPRSS2 KO mice infected with MA-B/Ibaraki/85[V]. | Scientific Reports

Figure 5: Body weights, survival, and histopathological findings of WT and TMPRSS2 KO mice infected with MA-B/Ibaraki/85[V].

From: TMPRSS2 Independency for Haemagglutinin Cleavage In Vivo Differentiates Influenza B Virus from Influenza A Virus

Figure 5

(A) WT and TMPRSS2 KO mice were intranasally inoculated with 2.0 × 103, 2.0 × 104, and 2.0 × 105 PFU of MA-B/Ibaraki/85[V] (n = 5 or 6). The body weights were measured daily. Filled and open triangles indicate data of WT and TMPRSS2 KO mice, respectively. Data represent means ± SD. (B) Survival curves of MA-B/Ibaraki/85[V]-infected mice. Blue and red lines indicate data of WT and TMPRSS2 KO mice, respectively. (C) Histopathological findings in the lungs of WT and TMPRSS2 KO mice infected with MA-B/Ibaraki/85[V]. Data obtained by HE staining and IHC for IBV antigens are shown. Original magnification: ×10. The inflammation scores of individual mice (n = 3) are shown.

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