Figure 1

Histopathology of BBN-induced bladder carcinoma in mouse model mimics progression of human urothelial CIS to invasive carcinoma.
(A) Histopathological analysis (H&E staining) of BBN-induced bladder carcinogenesis at indicated time and stages with typical morphology changes. (B) Immunohistochemical staining of tumor tissues from BBN or vehicle treated groups were fixed and immunostained by K5, k14 and Ki-67 antibodies, respectively.