Figure 6 | Scientific Reports

Figure 6

From: Conditional ablation of TGF-β signaling inhibits tumor progression and invasion in an induced mouse bladder cancer model

Figure 6

TGF-β signaling inhibitor reduced BBN-induced tumor invasion.

(A) Schematic diagrams show the experimental strategies. 8 Balb/c mice were administrated with LY364947 or vehicle after 26 weeks of BBN exposure, respectively. 4 weeks after the LY364947 injection, mice were sacrificed and bladders samples were analyzed by immunostaining. (B) Quantification of tumor lesion size from different treatment groups. Statistical analysis was performed by Student’s t-test. *p < 0,05; n = 8. (C) H&E staining and immuohistochemical analysis of bladders cancer samples from LY364947 or vehicle injected mice with BBN exposure by Ki-67 and active-caspase3 (AcCap3) antibodies. (D) Quantification of the Ki67 and Accap3 positive cells ratio in the indicated sections *P < 0.05.

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