Figure 6: Alignment of the DII S1–S2 region of insect NaV channels and human NaV1.5. | Scientific Reports

Figure 6: Alignment of the DII S1–S2 region of insect NaV channels and human NaV1.5.

From: Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami

Figure 6

Regions corresponding to the S1 and S2 transmembrane helices are shaded grey, and the numbering above the sequences corresponds to Blattella germanica BgNaV1. Sequence changes relative to the BgNaV1 sequence shown at the top of the alignment are highlighted in blue. The resistance-conferring Tyr at position 805 is highlighted in red when present. Note the vastly different S1–S2 loop sequence in the human NaV1.5 channel (bottom sequence).

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