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Figure 1

From: Live attenuated Salmonella displaying HIV-1 10E8 epitope on fimbriae: systemic and mucosal immune responses in BALB/c mice by mucosal administration

Figure 1

Characterization of live attenuated recombinant Salmonella expressing HIV-1 10E8 epitope on fimbriae.

(a) Expression of chimeric AgfA::10E8 protein in ST-10E8 strain detected by western blot analysis using anti-AgfA polyclonal sera and mAbs 10E8 and 4E10. (b) Congo red tests on ST-10E8, ST and AgfA-deficient strain (ST-∆AgfA). (c,d) Survival rates of mice (10 per group) infected with ST-10E8 or ST strain from 107 to 1011 CFU. (e,f) Colonization of ST-10E8 or ST strain in spleen and Peyer’s patches (12 mice per group). Data shown as mean ± SD of 5 mice in each group.

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