Figure 1
From: FGF21 ameliorates the neurocontrol of blood pressure in the high fructose-drinking rats
The cardiovascular protective effects of rhFGF21 administration (i.p) in HFD rats.
(A) The SBP of control (CTL) and HFD rats with rhFGF21 infusion (i.p) for 3 weeks (3w), n = 8 for each group; (B,C) The MAP (mmHg) and heart rate (HR) baselines; (D,E) The BRS (bpm/mmHg) induced by PE or SNP-1/3/10 (phenylephrine or sodium nitroprusside at concentration of 1, 3 or 10 μg/kg). n = 4–8 for each group in (B–E). Results were analyzed using two-way ANOVA followed by Bonferroni’s post hoc test and averaged data were presented as mean ± SEM. *P < 0.05 and **P < 0.01 vs. CTL + saline, †P < 0.05 and ††P < 0.01 vs. HFD + saline.
