Figure 3
From: FGF21 ameliorates the neurocontrol of blood pressure in the high fructose-drinking rats
The acute intravenous rhFGF21 injections in HFD rats.
(A) The MAP after rhFGF21 injection (i.v) within 1 hour, n = 5 for each group. (B) The BRS (PE, 3 μg/kg) change relative to basline (fold) at 10, 30 and 60 min after rhFGF21 injection, n = 5–6 for each group. (C) The Akt signal activation in the NTS at 10, 30 and 60 min after the rhFGF21 injections (i.v), n = 3–4 duplications from 12–15 rats for each group. (D) The eNOS signal activation in the NTS, n = 4 duplications from 12–16 rats for each group. (E) The nitric oxide (NO) concentrations in the NTS (n = 8 for each group). (F) The Akt signal activation in the NG at 10, 30 and 60 min after the rhFGF21 injections (i.v), n = 3–4 duplications from 12–15 rats for each group. p-, phosphorylated; t-, total. Results were analyzed using two-way ANOVA followed by Bonferroni’s post hoc test and averaged data were presented as mean ± SEM. NS, not significant, *P < 0.05 vs. baseline. Gels have been cropped for clarity; the bands were confirmed by the comparison with full-length gel images (Supplementary Figure S7) and molecular weight.
