Table 2 Summary of the significantly differentially expressed proteins in DES subgroups compared to CTRL employing the targeted proteomics strategy.

Gene names	Peptides [AA-sequences]	m/z [Da]	Charge [+]	MZ + [Da]	Score	Two samples t-test; (*Significant P<0.05)
						DRYlip vs. CTRL		DRYaq vs. CTRL		DRYaqlip vs. CTRL
						Significant	p value	Significant	p value	Significant	p value
PRR4	FPSVSLQEASSFFQR	865.43	2	1728.847	344	decrement	0.0004	decrement	0.0000	decrement	0.0000
PRR4	FPSVSLQEASSFFR	801.40	2	1600.789	340	decrement	0.0004	decrement	0.0000	decrement	0.0000
ZG16B	YFSTTEDYDHEITGLR	973.94	2	1945.869	127	decrement	0.0016	decrement	0.0000	decrement	0.0000
SCGB2A1	TINSDISIPEYK	690.35	2	1378.698	197	non-significant	0.0588	decrement	0.0008	decrement	0.0000
DMBT1	FGQGSGPIVLDDVR	730.38	2	1458.747	187	non-significant	0.1682	decrement	0.0228	decrement	0.0000
PROL1	FSQAVILSQLFPLESIR	974.55	2	1947.083	200	decrement	0.0081	decrement	0.0001	decrement	0.0000
LACRT	SILLTEQALAK	593.85	2	1185.697	255	non-significant	0.3401	non-significant	0.0521	decrement	0.0436
ALDH3A1	SLEEAIQFINQR	724.38	2	1446.747	135	non-significant	0.1853	non-significant	0.3497	increment	0.0083
ENO1	GNPTVEVDLFTSK	703.86	2	1405.709	155	non-significant	0.2672	increment	0.0256	increment	0.0037
TF	HSTIFENLANK	637.33	2	1272.646	84	non-significant	0.3587	increment	0.0000	increment	0.0000
S100A8	ALNSIIDVYHK	636.85	2	1271.687	142	increment	0.0229	increment	0.0004	increment	0.0000
PEBP1	GNDISSGTVLSDYVGSGPPK	975.48	2	1948.938	98	non-significant	0.7171	increment	0.0007	increment	0.0000
ORM1	YVGGQEHFAHLLILR	876.98	2	1751.947	127	non-significant	0.4548	increment	0.0004	increment	0.0000
S100A9	NIETIINTFHQYSVK	903.97	2	1805.931	342	increment	0.0001	increment	0.0000	increment	0.0000

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