Table 1 Evaluation of mannose-binding lectin phenotype and genotype in relation to the Crohn’s disease phenotype.

From: Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn’s Disease Patients

MBL2 rs5030737

Wild-type (G/G)

Heterozygote (G/A)

Mann-Whitney P(α = 0.05)

Number (%)

60 (87%)

9 (13%)

 

Behaviour, n (%)

 B1

35 (58.3%)

2 (22%)

 

 B2

12 (20%)

4 (44.4%)

 

 B3

11 (18.3%)

3 (33.3%)

 

 IBDU

2 (3.3%)

–

 

ASCA level (AU)

56.55

110.4

<0.05

MBL level (ng/mL)

3211.9

366.4

<0.0001

MBL-MASP activity (%EF/ng of MBL)

0.35

0.13

<0.05

  1. IBDU: inflammatory bowel disease not identified; AU: arbitrary unit; ASCA: anti-Saccharomyces cerevisiae antibodies; MBL: mannose-binding lectin; MASP: mannose-associated serine protease; EF: emitted fluorescence.
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