Table 2 Relationship between the rs2066844 NOD2 polymorphism and clinical phenotype of Crohn’s disease.

From: Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn’s Disease Patients

NOD2 rs2066844

Wild-type (C/C)

Heterozygote (C/T)

Mann-Whitney P (α = 0.05)

Number (%)

50 (72.5%)

19 (27.5%)

 

Behaviour

 B1

23 (46%)

14 (73.3%)

 

 B2

13 (26%)

3 (15.8%)

 

 B3

12 (24%)

2 (10.5%)

 

 IBDU

2 (4%)

–

 

ASCA level (AU)

62.8

66.7

ns

MBL level (ng/mL)

3046.5

2299.46

ns

MBL-MASP activity (%EF/ng of MBL)

0.38

0.16

p < 0.05

  1. IBDU: inflammatory bowel disease not identified; AU: arbitrary unit; ASCA: anti-Saccharomyces cerevisiae antibodies; MBL: mannose-binding lectin; MASP: mannose-associated serine protease; EF: emitted fluorescence.
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