Figure 3: Muscle-specific ROCK1 activation impairs energy metabolism. | Scientific Reports

Figure 3: Muscle-specific ROCK1 activation impairs energy metabolism.

From: ROCK1 reduces mitochondrial content and irisin production in muscle suppressing adipocyte browning and impairing insulin sensitivity

Figure 3

(a,b) The day-cycle and night-cycle of oxygen consumption (VO2) and carbon dioxide generation (VCO2) analyzed by indirect calorimetry in CTL and mCaROCK1 mice, the values were normalized with lean body mass. (c) Respiratory exchange ratio of mCaROCK1 and CTL mice during day and night cycle. (d) mCaROCK1 mice have decreased heat expenditure. All data are presented as the mean ± SEM, n = 7. *p < 0.05 or **p < 0.01 mCaROCK1 vs. CTL.

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