Figure 3: Detailed view of the interaction between nucleozin and NP.
From: Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites
The two NP chains interacting with nucleozin or compound 3 were shown as cartoon and coloured in blue and yellow or blue and green, respectively. Residues interacting with nucleozin or compound 3 (Y289, L306, N309, R382, R384, Y52, Y313 and R99) and the two compounds (nucleozin and compound 3) were shown as stick models. (A) Key NP-nucleozin interactions in one NP trimer were shown as dashed lines. Nucleozin was shown with magenta carbons. (B) Comparison of the two nucleozin molecules (magenta and green) in the asymmetric unit. The two NP-nucleozin complexes were superimposed and key interactions between nucleozin and NP were shown as dashed lines. (C) Structural comparison between nucleozin-bound and Compound 3 bound NP. Nucleozin was shown with magenta carbons and Compound 3 with brown carbons. Key interaction residues were shown as stick models and labelled.
