Figure 3 | Scientific Reports

Figure 3

From: TERT promoter mutations in pancreatic endocrine tumours are rare and mainly found in tumours from patients with hereditary syndromes

Figure 3

PML immunofluorescence combined with Tel-FISH in U2OS, CM and QGP cell lines.

U2OS cell line represents a universal positive control for ALT mechanism. CM cell line, a TERTp wild-type cell line, presented a high co-localization of telomeric DNA with PML exhibiting an ALT positive phenotype. QGP1, the TERTp mutated cell line does not present frequent co-localization of telomeric DNA with being ALT negative. These findings recapitulate the observations in our series of PETs.

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