Figure 5: Persistence random walk model parameterized by cellular migration speed and directional persistence time. | Scientific Reports

Figure 5: Persistence random walk model parameterized by cellular migration speed and directional persistence time.

From: Multiscale Cues Drive Collective Cell Migration

Figure 5

Cell migration speed of MCF-10A wild type cells (A) and oncogenic PIK3CA knockin cells (B) responsive to substrate nanotopography, and on flat and nanogrooved substrate to cell type based on ECM pattern geometry. Persistence time of MCF-10A cells (C) and oncogenic PIK3CA knockin cells (D) on ECM patterned flat and nanogrooved PDMS substrates were calculated by fitting the mean-squared displacement of cell path data to the persistent random walk model. Error bars represent standard deviations of three technical replicates with 40–50 cells per each experiment and statistical significance is indicated by P values (*p < 0.05).

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