Table 1 Human candidate retinal proteins (FDR <1%) that were A1. documented exclusively in the control group based on zero LFQ values in the glaucoma group and therefore named “unique”; A2. significantly (p < 0.05) or distinctly (p < 0.1) decreased in the glaucoma group; B1. documented exclusively in the glaucoma group based on zero LFQ values in the control group and therefore named “unique”; B2. significantly (p < 0.05) or distinctly (p < 0.1) increased in the glaucoma group.

A1: “Unique” control retinal proteins

V-type proton ATPase 116 kDa subunit a isoform 1 (VPP1)

Arrestin-C (cArr)

Protein NipSnap homolog 3A

Heterogeneous nuclear ribonucleoprotein Q (hnRPQ)

6-phosphofructokinase, liver type

Elongation factor Tu, mitochondrial

40S ribosomal protein S19

Peripherin-2

Protein SET

Reticulocalbin-2

A2: Glaucoma decreased retinal proteins

Calcium-binding mitochondrial carrier protein Aralar2

Methyl-CpG-binding protein 2 (MeCp2)

NADH dehydrogenase [ubiquinone] 1 ß subcomplex sub. 9 (CI-B22)

40S ribosomal protein S7

3-hydroxyacyl-CoA dehydrogenase type-2

Trifunctional enzyme subunit α, mitochondrial

Myosin-11/9

60S acidic ribosomal protein P0; P0-like

Pyruvate dehydrogenase E1 comp. sub. ß, mitochondrial (PDHE1-B)

High mobility group protein HMG-I/HMG-Y

Small nuclear ribonucleoprotein Sm D3

(ATP-dependent) 6-phosphofructokinase, muscle type

Vesicle-fusing ATPase

Heterogeneous nuclear ribonucleoprotein L

PC4 and SFRS1-interacting protein (DFS70)

Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2)

ADP/ATP translocase 3 (ANT3)

Ras-related protein Rab-11A; B

Heterogeneous nuclear ribonucleoprotein U

Histone H1.0

Putative elongation factor 1-α-2;1; like 3

Guanine nucleotide-binding protein G(i) subunit α-2

B1: “Unique” glaucoma retinal proteins

Protein name

Glutathione synthetase

Septin-8

Opticin

Calcium-binding mitochondrial carrier protein Aralar1

Serpin B6

Neuroplastin

Carbonyl reductase [NADPH] 1

4-trimethylaminobutyraldehyde dehydrogenase

ß-crystallin A3;isoform A1/Σ4/Σ7/Σ8

Ig γ-2 chain C region

ß-crystallin B1

Phakinin

α-1-antitrypsin;Short peptide from AAT

Sideroflexin-1

X-ray repair cross-complementing protein 5

N(G), N(G)-dimethylarginine dimethylaminohydrolase 1

Hippocalcin-like protein 1

Thy-1 membrane glycoprotein

V-type proton ATPase subunit G 1/G2

Cytosolic non-specific dipeptidase

B2: Glaucoma increased retinal proteins

Retinal dehydrogenase 1 (RALDH 1)

High mobility group protein B1; Putative B1-like 1

Vesicle-associated membrane protein-associated protein B/C

Annexin A2; Putative A2-like

Reticulon-3

Glutathione S-transferase Mu 3 (hGSTM3-3)

Dihydropteridine reductase

Retinol-binding protein 3 (IRBP)

α-crystallin B chain (HspB5)

Endoplasmin

Serotransferrin

Rab GDP dissociation inhibitor α