Table 2 Subset of representative human retinal candidate proteins selected for AIMS validation in retina sample pools.

From: Glaucoma related Proteomic Alterations in Human Retina Samples

Protein

Gene names

Mass [Da]

m/z

Amino acid sequence

Charges

Glaucoma/Control

Valid

ADP/ATP translocase 3 (ANT3)

SLC25A6

1232,68

617,34

DFLAGGIAAAISK

2

0,38

PC4 and SFRS1-interacting protein (DFS70)

PSIP1

1631,76

816,88

GFNEGLWEIDNNPK

2

0,80

Methyl-CpG-binding protein 2 (MeCp2)

MECP2

1954,89

978,45

VGDTSLDPNDFDFTVTGR

2

0,65

α-crystallin B chain (HspB5)

CRYAB

1164,65

583,33

VLGDVIEVHGK

2

1,08

×

Arrestin-C (cArr)

ARR3

1821,94

911,97

VQFAPPEAGPGPSAQTIR

2

0,99

×

  1. Analysis of technical replicate runs (N = 4; N = 4 individuals/pool sample) supported glaucoma related significant level diminishment of ANT3, MeCp2 and distinct decline of DFS70 highlighted by check mark in the column.