Figure 5
Neutrophils infiltration is associated with increased cell proliferation and also dissociated proliferating cells.
(A) Neutrophil density is positively correlated with gastric epithelium cell proliferation in gastritis suggesting neutrophils might promote cell proliferation. Scale bar, 200 μm. (B) Neutrophils dissociate proliferating cells in gastritis. Arrows pointed to Ki67 positive cells intermingled with neutrophils. Scale bar: 100 μm (C) Detection of single proliferating gastric epithelium cell or small proliferating gastric epithelium cell clusters using triple antibody labeling. a), Single dissociated E-cadherin/beta-Catenin/Ki67 positive cells could be detected in gastritis tissues (Magnified images showed the single triple positive cell labeled with “*”. Scale bar, 100 μm; b), a two cell cluster with one Ki67 positive cell detected with another combination of E-cadherin/beta-Catenin/Ki67 triple antigen staining. Magnified images showed the E-cadherin/beta-Catenin/Ki67-positive 2 cell cluster. Scale bar, 50 μm.
