Table 2 Master regulators associated with HPV16 E6 protein.

From: Identification of host transcriptional networks showing concentration-dependent regulation by HPV16 E6 and E7 proteins in basal cervical squamous epithelial cells

Master Regulator Analysis

Correlation with E6 protein

Master Regulator

Regulon Size

Hits

Adj. P value

Cor p-val

r

EGR3

20

15

1.3e-14

1.920077e-05

−0.5749358

FOSB

26

14

9.6e-11

8.02598e-05

−0.5379808

SOX9

15

7

1.1e-05

0.01122992

−0.3629557

PRDM1

19

7

5.8e-05

0.0002166108

−0.5095245

MNT

19

7

5.8e-05

0.09426613

−0.2442864

NR4A2

13

5

3.1e-04

0.0004620858

−0.4859879

OVOL1

16

5

1.0e-03

0.02640054

−0.320413

  1. The left side of the Table refers to the Master Regulator Analysis. ‘Regulon Size’ is the number of ARACNe-inferred gene targets of each master regulator, while ‘Hits’ gives the numbers of those genes for which expression levels were significantly associated with levels of HPV16 E6. The p-values were determined using Fisher’s exact test. The right side of the Table refers to testing of individual correlations between levels of the master regulators and those of E6 protein, where the p-value refers to deviation from no correlation and r is the correlation coefficient.
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