Figure 1: Tumour formation in the brain after stem cell transplantation. | Scientific Reports

Figure 1: Tumour formation in the brain after stem cell transplantation.

From: Tumourigenicity and Immunogenicity of Induced Neural Stem Cell Grafts Versus Induced Pluripotent Stem Cell Grafts in Syngeneic Mouse Brain

Figure 1

(a) The percent survival of animals in the ESC, iPSC, NSC, iNSC and MSC groups (n = 21/group) during the 28-day observation period. (b) The percent survival of animals in the NSC, iNSC and MSC groups (n = 21/group) during the 24-week observation period. (c) The gross morphology of brains in the ESC, iPSC, NSC, iNSC, MSC and Control groups on day 14 post-implantation (NT: no tumour formation). (d) Weight and representative pictures of brain tumours in the ESC (G1), iPSC (G1), ESC (G2), iPSC (G2), ESC (G3) and iPSC (G3) groups on day 14 post-implantation (n = 6/group; (a) P < 0.05 versus grade 2 or grade 1; (b) P < 0.05 versus grade 1). (e) Malignant teratoma formation correlated with severe brain injury and massive immune cell infiltration was detected in the brains of mice subjected to syngeneic ESC grafts on day 14 post-implantation ((B) brain tissue; T: tumour tissue). (f) Benign teratoma formation, including (I) cartilage tissue, (II) adenoid tissue, (III) sebaceous gland, (IV) bronchial epithelium tissue, (V) neural tissue and (VI) muscle tissue, was observed in the brains of mice subjected to syngeneic iPSC grafts on day 14 post-implantation (B: brain tissue; T: tumour tissue). Scale bar = 2 mm (c,d); 1 mm (e,f); 100 μm ((f) I–VI).

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