Figure 1
From: Parkinson-like phenotype in insulin-resistant PED/PEA-15 transgenic mice
Behavioral and histochemical phenotyping of tgPED mice.
(A) ‘Aged’ appearance (pronounced hump and grayish coat hair) of tgPED mice compared to wild type littermates. (B,C) Impaired negative geotaxis indexed as (B) the time to reach the top and (C) the time to turn around from a head-down position. (D) Impaired motor learning ability of tgPED mice. tested using repeated exposures to the rotarod test. (E,F) modified metabolic activity in the striatum of tgPED mice quantified using the cytochrome oxidase staining on sagittal sections ((E) pseudocolor images; (F) relative optical density). *p < 0.05 vs. wt mice (t-test for non-paired data).
