Table 2 5-HT, h-5-HT and 5-HIAA levels are correlated with 5-HT related genes in the lungs of bleomycin treated rats (n = 20).

From: Serotonin biosynthesis as a predictive marker of serotonin pharmacodynamics and disease-induced dysregulation

Metabolite

Gene

Rank

Spearman r

p value

lung 5-HT (ng/lung)

Tph1

1/69

0.7654

<0.0001

lung 5-HT (ng/lung)

Slc6a4

2/69

0.6932

0.0007

lung 5-HIAA (ng/lung)

Htr2a

1/69

−0.797

<0.0001

lung 5-HIAA (ng/lung)

Slc6a4

2/69

0.788

<0.0001

lung h-5-HT (ng/lung)

Tph1

1/69

0.5534

0.0114

  1. A Spearmen correlation was performed for the listed metabolites against a panel of 69 genes and the r and p values for key top ranking correlations are given. Rank for the 69 genes was based on Spearman r (1 highest r, to 69 lowest r), after multiplication of negative correlations by −1.
Back to article page