Table 4 Top 10 diminished proteins identified in CR compared to CN ascites tumor cells.
From: Unique proteome signature of post-chemotherapy ovarian cancer ascites-derived tumor cells
Protein Accession | Gene symbol | Protein Description | CN | CR | RSC | Gene ontology (GO) |
|---|---|---|---|---|---|---|
B7Z416 | DHRS9 | Dehydrogenase/reductase SDR family member 9 | 48 | 46 | −13.0 | oxidation-reduction process; oxidoreductase activity |
Q16647 | PTGIS | Prostacyclin synthase | 43 | 40 | −8.7 | apoptotic signaling pathway; cellular response to hypoxia; cellular response to interleukin-1; cellular response to interleukin-6; cyclooxygenase pathway; endoplasmic reticulum membrane; extracellular space; heme binding; integral component of membrane; iron ion binding; monooxygenase activity; negative regulation of NF-kappaB transcription factor activity; negative regulation of inflammatory response; negative regulation of nitric oxide biosynthetic process; nucleus; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; positive regulation of angiogenesis; positive regulation of execution phase of apoptosis; positive regulation of peroxisome proliferator activated receptor signaling pathway; prostaglandin-I synthase activity; xenobiotic metabolic process |
B4DKB2 | ECE1 | Endothelin-converting enzyme 1 | 42 | 38 | −6.7 | metalloendopeptidase activity; proteolysis |
K7EKI8 | PPL | Periplakin | 211 | 187 | −6.4 | cytoskeleton |
P26583 | HMGB2 | High mobility group protein B2 | 14 | 13 | −5.7 | DNA binding, bending; DNA topological change; RAGE receptor binding; apoptotic DNA fragmentation; base-excision repair, DNA ligation; cell chemotaxis; cellular response to lipopolysaccharide; chemoattractant activity; damaged DNA binding; double-stranded DNA binding; extracellular space; male gonad development; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of transcription, DNA-templated; nucleosome assembly; phosphatidylinositol-mediated signaling; positive regulation of DNA binding; positive regulation of endothelial cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of megakaryocyte differentiation; positive regulation of nuclease activity; positive regulation of transcription from RNA polymerase II promoter; protein complex; response to steroid hormone; sequence-specific DNA binding transcription factor activity; single-stranded DNA binding; transcription regulatory region DNA binding |
P09913 | IFIT2 | Interferon-induced protein with tetratricopeptide repeats 2 | 14 | 13 | −5.7 | RNA binding; apoptotic mitochondrial changes; cellular response to interferon-alpha; cytosol; defense response to virus; endoplasmic reticulum; negative regulation of protein binding; positive regulation of apoptotic process; response to virus; type I interferon signaling pathway |
Q13753 | LAMC2 | Laminin subunit gamma-2 | 34 | 30 | −5.3 | cell adhesion; cell cortex; epidermis development; extracellular matrix organization; extracellular region; extracellular space; hemidesmosome assembly; heparin binding; laminin-2 complex; laminin-5 complex; membrane; perinuclear region of cytoplasm |
A8K8G0 | HDGF | Hepatoma-derived growth factor | 33 | 29 | −5.1 | NA |
P43155 | CRAT | Carnitine O-acetyltransferase | 12 | 11 | −4.9 | carnitine O-acetyltransferase activity; carnitine metabolic process, CoA-linked; endoplasmic reticulum; fatty acid beta-oxidation using acyl-CoA oxidase; mitochondrial inner membrane; mitochondrion; peroxisomal matrix; transport |
P08582 | MFI2 | Melanotransferrin (Melanoma-associated antigen p97) (CD228) | 12 | 11 | −4.9 | anchored component of membrane; cellular iron ion homeostasis; extracellular region; ferric iron binding; integral component of plasma membrane; iron ion binding; iron ion transport |
