Figure 4 | Scientific Reports

Figure 4

From: TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling

Figure 4

Suppression of p38 and JNK activations reduced levels of the inflammatory cytokines in vital organs at 24 h post severe burn.

(A) Administrations of human umbilical cord-MSCs and P38, JNK inhibitors significantly reduced levels of TNF-α in liver, kidney, lung, heart and spleen post severe burn. (B–D) Compared with that of sham group, the levels of IL-1β, IL-6 and MPO in these vital organs of burn group were remarkably increased and they were significantly decreased by human umbilical cord-MSCs and P38, JNK inhibitors administrations. Values are represented as mean ± SD (n = 6). A single (@) and double (@@) stand for p < 0.05 and p < 0.01 compared with sham group, respectively. Asterisk (*) and double asterisk (**) stand for p < 0.05 and p < 0.01 compared with burn group, respectively.

Back to article page