Figure 6 | Scientific Reports

Figure 6

From: TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling

Figure 6

The effects of TSG-6 level on the systemic inflammatory responses induced by severe burn.

(A,B) Administrations of human umbilical cord-MSCs with TSG-6 siRNA knockdown did not improve temperature and leukocyte counts. However, rhTSG-6 administration significantly improved temperature and leukocyte counts, which were closed to normal. (C–F) Administrations of human umbilical cord-MSCs with TSG-6 siRNA knockdown significantly reduced the therapeutic effect of the human umbilical cord-MSCs on anti-inflammatory cytokine of IL-10 and pro-inflammatory cytokines of TNF-α, IL-1β, IL-6 in serum after severe burn, but rhTSG-6 administration greatly improved the levels of the pro-inflammatory and anti-inflammatory cytokines. Values are represented as mean ± SD (n = 6). A sterisk (*) and double asterisk (**) stand for p < 0.05 and p < 0.01 compared with burn group, respectively.

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