Figure 8 | Scientific Reports

Figure 8

From: TSG-6 secreted by human umbilical cord-MSCs attenuates severe burn-induced excessive inflammation via inhibiting activations of P38 and JNK signaling

Figure 8

The effects of TSG-6 level on expression of the inflammatory cytokines in vital organs at 24 h post severe burn.

The therapeutic effects of human umbilical cord-MSCs on levels of the inflammatory cytokines, such as TNF-α (A), IL-1β(B), IL-6 (C) and MPO (D) in liver, kidney, lung, heart and spleen were significantly decreased after TSG-6 siRNA knockdown and rhTSG-6 administration got a good anti-inflammatory effects for these inflammatory cytokines in vital organs. Values are represented as mean ± SD (n = 6). A sterisk (*) and double asterisk (**) stand for p < 0.05 and p < 0.01 compared with burn group, respectively.

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