Figure 1: Maternal inflammation aggravates cardiac systolic dysfunction caused by 2 weeks of isoproterenol stimulation in adult offspring. | Scientific Reports

Figure 1: Maternal inflammation aggravates cardiac systolic dysfunction caused by 2 weeks of isoproterenol stimulation in adult offspring.

From: Maternal inflammation activated ROS-p38 MAPK predisposes offspring to heart damages caused by isoproterenol via augmenting ROS generation

Figure 1

Pregnant SD rats were administered intraperitoneally (i.p) with saline (Control group) or LPS (0.79 mg/kg, LPS group) at gestational day (GD) 8, 10 and 12. Offspring from both control and LPS group at the age of 20 weeks were treated with vehicle (Con + Ve group and LPS + Ve group, respectively) or ISO (Con + ISO group and LPS + ISO group, respectively) for 2 weeks. (a) At the end of ISO treatment, cardiac function was assessed by echocardiography. Representative photo-micro- graphs from M-mode echocardiography. (b) Left ventricular systolic function index. LVEF%: left ventricular ejection fraction; LVFS%: left ventricular fractional shortening. (c) Left ventricular diastolic function index. LVIDD: Left ventricular end diastolic internal dimension; LVEDV: Left ventricular end diastolic volume; LVPWD: Left ventricular end diastolic posterior wall dimension. Error bar represents S.D. n = 15 offspring in Con + Ve and LPS + Ve group, n = 11 offspring in Con + ISO and LPS + ISO group. *p < 0.05, **p < 0.01, ***p < 0.001 and #p < 0.05 denote the statistical comparison between the two marked treatment groups, respectively. Two-way ANOVA.

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