Figure 1 | Scientific Reports

Figure 1

From: Astragaloside IV improves lipid metabolism in obese mice by alleviation of leptin resistance and regulation of thermogenic network

Figure 1

ASI prevented weight gain and reduced adipose tissue in HFD fed mice.

(A) ASI administered at 25 mg/kg/d for 13 weeks prevented weight gain of HFD fed mice. Compared with HFD fed group mice, ASI treated HFD fed mice showed significantly lower increase in body weight from week 7 to week 13. N = 7–8/group. (B) ASI treated HFD fed mice displayed lower accumulative body weight change. N = 7–8/group. (C) ASI treated HFD fed mice accumulated less fat in subcutaneous (yellow) and visceral (purple) tissues. In addition, adipocytes in ASI treated mice kept the regular size as that in CD group mice as observed under scanning electron microscopy. Scale bar equals to 100 μm. (D) ASI treated mice had less epididymal WAT. N = 4–5/group. (E) ASI treatment reduced the ratio of WAT to body weight of HFD fed mice. N = 5/group. Data were presented as mean ± S.E.M. Compared with HFD group, *p < 0.05; **p < 0.01; ***p < 0.001.

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