Figure 6 | Scientific Reports

Figure 6

From: Astragaloside IV improves lipid metabolism in obese mice by alleviation of leptin resistance and regulation of thermogenic network

Figure 6

ASI enhanced leptin sensitivity in HFD fed mice.

(A) Effect of ASI on serum leptin level. N = 4–6/group. (B) Effect of ASI on leptin mRNA expression level in WAT. N = 4–6/group. (C,D) Effect of ASI on hypothalamic ObR A and B mRNA expressions. N = 4–6/group. (E) Effect of ASI on hypothalamic genes associated with appetite in HFD fed mice. N = 4–6/group. (F) ASI treatment did not change mRNA expression levels of hypothalamic genes involved in regulation of appetite in db/db mice. N = 6/group. Data were presented as mean ± S.E.M. Compared with HFD group, *p < 0.05; **p < 0.01; ***p < 0.001.

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