Figure 3 | Scientific Reports

Figure 3

From: Oral CoQ10 attenuates high salt-induced hypertension by restoring neurotransmitters and cytokines in the hypothalamic paraventricular nucleus

Figure 3

Effects of CoQ10 on PVN levels of the superoxide and Cu/Zn-SOD proteins expression in the PVN of high salt-induced hypertensive rats.

ROS activity was measured by fluorescent-labeled dihydroethidium (DHE) staing and Cu/Zn-SOD proteins were measured by Western blot. Results of showed that HS rats had stronger fluorescence intensity labeled with DHE and lower Cu/Zn-SOD level compared with NS rats (P < 0.05, n = 7). 15-week of CoQ10 administration by gavage at the dose of 10 mg/kg/day significantly decreased DHE staining and increased Cu/Zn-SOD protein expression (P < 0.05, n = 7). (A) A representative immunofluorescence image of DHE. (B) Densitometric analysis of immunofluorescent intensity of DHE in the PVN in different groups. (C) A representative immunoblot of Cu/Zn-SOD. (D) Densitometric analysis of protein expression of Cu/Zn-SOD in the PVN in different groups. Values are expressed as means ± SE. *P < 0.05 vs control (NS + oil or NS + CoQ10), †P < 0.05, HS + CoQ10 vs HS + oil, 3V, third ventricle.

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