Figure 5 | Scientific Reports

Figure 5

From: M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma

Figure 5

Depletion of macrophages or administration of the legumain inhibitor suppresses tumour progression in the OCI-Ly3 xenograft mouse model of DLBCL.

The OCI-Ly3 xenograft mouse model of DLBCL was treated with clodrolip (25 mg/kg), the legumain inhibitor (0.2 mg/kg), or the vehicle only (control). (A) Schematic of the experimental design. (B) Tumour growth curves. (C) Immunofluorescence staining of F4/80 and CD 206 in clodrolip and control groups. Scale Bar = 50 μm. (D) RT-PCR analysis of F4/80 and CD206 mRNA expression. The right panel shows the statistical results. (E) Immunohistological staining of CD31. The left panel shows representative images and the right panel is the statistical result. Scale Bar = 100 μm. (F,G) Representative images and statistical bar graph of sirus red staining and immunohistological staining of collagen I. Scale Bar = 100 μm. Data are shown as the mean ± s.e.m. *P < 0.05, **P < 0.01 and ***P < 0.001.

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