Figure 3: The brain microenvironment preselected dormant DMC-derived cells with a new phenotype. | Scientific Reports

Figure 3: The brain microenvironment preselected dormant DMC-derived cells with a new phenotype.

From: Melanoma dormancy in a mouse model is linked to GILZ/FOXO3A-dependent quiescence of disseminated stem-like cells

Figure 3

Dormant DMC-derived B16F1-GFP-D cells persisting asymptomatically in the brains of mice bearing primary tumours overexpressed factors that potentially facilitated their in vitro propagation. RT-PCR was performed to analyse Ccnd2, Rxrb, Nupr1, Cdc25a and Id3 expression in B16F1-GFP-DB #1, #2 and #3 brain-derived GFP+ cells and in their respective primary tumours #1, #2 and #3. The values represent the levels of each transcript in the brain-derived B16F1-GFP-DB cells relative to the average levels of the corresponding transcripts (set to 1) in three B16F1-GFP-D-initiated tumours.

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