Figure 6 | Scientific Reports

Figure 6

From: Human DNA-Damage-Inducible 2 Protein Is Structurally and Functionally Distinct from Its Yeast Ortholog

Figure 6

Solution structure of hDdi2 HDD.

(A) Superimposition of 30 converged structures of HDD. (B) Structural alignment of hDdi2 HDD and yDdi1 HDD (PDB code 5KES) analyzed by Dali Pairwise comparison37. The Z score for these two structures is 4 and their RMSD is 5 Å. Secondary structures are shown; bars connect identical amino acids. (C) Hydrophobic core of the HDD bundle supported by a salt bridge between helix 3 and the initial part of helix 4, including residues Ser165 and Lys170, with occasional contribution from Glu161 (D) Superimposition of hDdi2 HDD (blue) with yDdi1 HDD (grey) represented by cylindrical helices. N-terminal parts of both HDDs superimpose with an RMSD of 0.95 Å.

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