Table 2 PAI-1 levels in several brain subregions, cerebrospinal fluid and serum of rats among different groups (M ± SEM).

From: Plasminogen Activator Inhibitor-1 in depression: Results from Animal and Clinical Studies

 

Normal + saline

Normal + Esc

CUMS + saline

CUMS + Esc

Cg1

0.22 ± 0.01

0.10 ± 0.00

0.88 ± 0.02**

0.67 ± 0.02##

PrL

0.32 ± 0.02

0.35 ± 0.02

0.81 ± 0.04**

0.55 ± 0.03##

CA1

0.43 ± 0.02

0.57 ± 0.02

0.25 ± 0.01**

0.27 ± 0.01

CA3

0.26 ± 0.01

0.12 ± 0.00

1.00 ± 0.04**

0.47 ± 0.02##

DG

0.60 ± 0.02

0.40 ± 0.01

0.93 ± 0.04**

0.69 ± 0.02##

CSF (ng/ml)

1.38 ± 0.22

2.95 ± 0.51

3.55 ± 0.32**

3.44 ± 0.18

Serum (ng/ml)

1.16 ± 0.17

4.66 ± 0.48

2.50 ± 0.50

0.74 ± 0.10#

  1. Note: The protein levels of PAI-1 in Cg1, PrL, CA1, CA3 and DG were normalized to GAPDH. M: mean; SEM: standard error of mean; Esc: escitalopram; CUMS: chronic unpredictable mild stress; Cg1: area 1 of the cingulate cortex; PrL: prelimbic cortex; CA1: cornu ammonis 1; CA3: cornu ammonis 3; DG: dentate gyrus. CSF: cerebrospinal fluid.
  2. Compared with “Normal + saline” group by post-hoc analysis, *P <0.05, **P < 0.01. Compared with “CUMS + saline” group by post-hoc analysis, #P < 0.05, ##P < 0.01.
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