Figure 3 | Scientific Reports

Figure 3

From: Molecular developmental mechanism in polypterid fish provides insight into the origin of vertebrate lungs

Figure 3

The mouse lung mesenchyme-specific enhancer (LME) of the Tbx4 gene.

(a) VISTA plots comparing the mouse LME sequences of the Tbx4 gene in human (Homo sapiens), chicken (Gallus gallus), frog (Xenopus tropicalis), coelacanth (Latimeria chalumnae), bichir (Polypterus senegalus), zebrafish (Danio rerio) and medaka (Oryzias latipes) with that in mouse (Mus musculus). The green dashed box indicates the conserved region in the LME. (b) Multiple sequence alignment of the conserved region among human, mouse, chicken, frog, coelacanth and bichir. A core lung mesenchyme-specific enhancer (C-LME) of 150 bp was found in bichir as well as the sarcopterygians, as shown in orange. The predicted binding sites of the transcription factors are indicated by blue boxes.

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