Figure 6: Prevalence of neuronal phenotypes within human VTA subdivisions.
From: Glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans
(A) Coronal section showing TH-expression in the human VTA. (B) Distribution of VGluT2-only neurons (green circles), TH-only neurons (blue triangles) and dual VGluT2-TH neurons (red circles) within the different subdivisions of the human VTA. A mixture of both VGluT2-only and TH-only neurons is present in the RLi. The highest prevalence of dual VGluT2-TH neurons is present in the PBP. The PN and the VTASUB are mostly populated by TH-only neurons. Data are mean ± SEM percent of the neuronal phenotype within each subdivision per analyzed section. (C-G”) Neuronal phenotypes detected within the human VTA subdivisions. C-D”. RLi detection of both VGluT2-only neurons (green arrows in C-C”) and dual VGluT2-TH neurons (red arrows in D-D”). E-E’. PBP detection of dual VGluT2-TH neurons (red arrows). (F-F”) VTASUB detection of TH-only neurons (blue arrows) and dual VGluT2-TH neurons (red arrows). (G-G”) PN detection of TH-only neurons (blue arrow) and VGluT2-only neurons (green arrows). Scale bar in A = 250 μm, scale bar in C = 25 μm and applies to C-C”, D-D”, E-E”, F-F”, and G-G”.
