Table 3 Human VTA neurons expressing VGluT2 mRNA or TH-immunoreactivity.

From: Glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans

VTA Subdivision

Subject

VGluT2-only

VGluT2-TH

TH-only

RLi

Subject 1

49.48% (n = 383)

14.86% (n = 115)

35.66% (n = 276)

Subject 2

34.6% (n = 228)

5.16% (n = 34)

60.24% (n = 397)

Mean ± SEM

42.04% ± 7.44%

10.01% ± 4.85%

47.95% ± 12.29%

PBP

Subject 1

11.47% (n = 53)

27.92% (n = 129)

60.61% (n = 280)

Subject 2

27.43% (n = 234)

6.8% (n = 58)

65.77% (n = 561)

Mean ± SEM

19.45% ± 7.98%

17.36% ± 10.56%

63.19% ± 2.58%

VTASUB

Subject 1

9.85% (n = 32)

9.54% (n = 31)

80.62% (n = 262)

Subject 2

17.14% (n = 60)

10% (n = 35)

72.86% (n = 255)

Mean ± SEM

13.49% ± 3.65%

9.77% ± 0.23%

76.74% ± 3.88%

PN

Subject 1

16.76% (n = 63)

2.66% (n = 10)

80.59% (n = 303)

Subject 2

9.8% (n = 20)

0.49% (n = 1)

89.71% (n = 183)

Mean ± SEM

13.28% ± 3.48%

1.57% ± 1.08%

85.15% ± 4.56%

  1. Percent refers to the number of neurons expressing VGluT2 mRNA without TH-immunoreactivity (VGluT2-only neurons), neurons co-expressing VGluT2 mRNA and TH-immunoreactivity (VGluT2-TH neurons), or neurons expressing TH-immunoreactivity without VGluT2 mRNA (TH-only neurons) divided by the total number of labeled neurons identified in each subject and in each subdivision of the VTA. Numbers in parentheses refer to number of counted neurons of each phenotype.