Figure 4: Ultrasound targeted hs-MB destruction limit the extent of MIR. | Scientific Reports

Figure 4: Ultrasound targeted hs-MB destruction limit the extent of MIR.

From: Delivery of Hydrogen Sulfide by Ultrasound Targeted Microbubble Destruction Attenuates Myocardial Ischemia-reperfusion Injury

Figure 4

(A) In vivo experimental protocol showing the groups, intervention and outcomes measurement. (B) Electrocardiogram of rats underwent myocardial ischemia and reperfusion. (C) Ultrasound imaging of myocardial perfusion during ischemia or reperfusion. Red dotted line indicated the region of myocardium. Red arrows indicated perfusion defect in the anterior wall. (D) Representative photographs of mid-ventricular cross sections stained with Evans/TTC. Dark blue stain indicated viable area; White stain indicated infarct region; White plus red stain indicated area at risk. (E) Comparison of area at risk per left ventricle (AAR/LV). (F) Comparison of area of infarct size normalized to the area at risk (IS/AAR). *P < 0.05. MIR indicates myocardial ischemia-reperfusion injury; c-MB, control microbubble; US, ultrasound; hs-MB, microbubble loaded with hydrogen sulfide; NS, not significant.

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