Figure 4: DHED treatment is not accompanied by typical estrogenic effects in the periphery | Scientific Reports

Figure 4: DHED treatment is not accompanied by typical estrogenic effects in the periphery

From: Treatment with an orally bioavailable prodrug of 17β-estradiol alleviates hot flushes without hormonal effects in the periphery

Figure 4

. (a–d) DHED, contrary to EE, does not stimulate the uterus; i.e., it does not increase epithelial cell height. Data represent mean ± SEM. *P < 0.05 compared with vehicle-treated OVX group. (e) DHED, contrary to EE, does not stimulate uterine wet weight. (f) DHED, contrary to EE does not stimulate the expression of galanin in the anterior pituitary as measured with quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). Data represent mean ± SEM. *P < 0.001 compared with vehicle-treated OVX group.

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