Table 1 Profiling of highly up-regulated genes after FGF2 exposure.

From: Fibroblast Growth Factor-2 facilitates the growth and chemo-resistance of leukemia cells in the bone marrow by modulating osteoblast functions

Gene Symbol

UniGene ID

Control average

FGF2 average

log2 ratio

Gene function

Aldh18a1

Mm.233117

423.4

1059.33

1.323

proline biosynthetic process

Igfbp4

Mm.233799

199.89

502.91

1.331

regulation of cell growth

Slc3a2

Mm.4114

737.44

1855.8

1.331

carbohydrate metabolic process

Pla2g4a

Mm.4186

173.5

440.59

1.344

ovulation from ovarian follicle

Oxnad1

Mm.202257

73.03

187.05

1.357

oxidation-reduction process

Efnb2

Mm.209813

122.81

327.22

1.414

angiogenesis

Hk2

Mm.255848

99.06

265.49

1.422

carbohydrate metabolic process

Fxyd5

Mm.1870

98.63

266.32

1.433

ion transport

Pck2

Mm.29856

437.49

1192.43

1.447

gluconeogenesis

Mtbp

Mm.390829

109.51

300.02

1.454

cell cycle arrest

Sox9

Mm.286407

150.94

419.28

1.474

skeletal system development

Adssl1

Mm.3440

137.24

381.46,

1.475

purine nucleotide metabolic process

Slc30a4

Mm.27801

442.23

1233.74

1.48

ion transport

Pdia4

Mm.2442

215.3

612.85

1.509

glycerol ether metabolic process

Tnfaip2

Mm.255332

121

350.83

1.536

angiogenesis

Shmt2

Mm.29890

646.21

1874.86

1.537

glycine metabolic process

Asns

Mm.2942

390.33

1150.26

1.559

asparagine biosynthetic process

Psph

Mm.271784

117.81

350.07

1.571

cellular amino acid biosynthetic process

Itga6

Mm.225096

101.61

312.63

1.621

cell adhesion

Ptgs1

Mm.275434

110.81

344.85

1.638

prostaglandin biosynthetic process

Vegfa

Mm.282184

581.59

1844.79

1.665

angiogenesis

Glce

Mm.24411

93.92

306.52

1.707

glycosaminoglycan biosynthetic process

Wars

Mm.38433

278.19

942.01

1.76

angiogenesis

Slc6a9

Mm.244549

69.4

235.35

1.762

amino acid transmembrane transport

Gnpnat1

Mm.312945

262.23

894.46

1.77

glucosamine metabolic process

Slc7a5

Mm.27943

536.41

1834.84

1.774

amino acid transmembrane transport

Rps6ka2

Mm.268383

211.14

726.49

1.783

mitotic metaphase

Mthfd2

Mm.443

280.94

967.4

1.784

one-carbon metabolic process

Got1

Mm.19039

297.57

1072.98

1.85

oxaloacetate metabolic process

Hyou1

Mm.116721

356.72

1327.73

1.896

response to hypoxia

Slc7a1

Mm.275489

85.44

321.68

1.913

amino acid transmembrane transport

Slc20a1

Mm.272675

133.78

524.25

1.97

ion transport

Cyb5r1

Mm.280230

93.62

368.25

1.976

steroid biosynthetic process

Hspa5

Mm.330160

423.59

1671.18

1.98

anti-apoptosis

Steap1

Mm.85429

113.69

452.85

1.994

ion transport

Aldh3a1

Mm.4257

354.18

1438.4

2.022

cellular aldehyde metabolic process

Sesn2

Mm.23608

80.94

344.09

2.088

cell cycle arrest

Aldh1l2

Mm.263138

117.96

513.09

2.121

one-carbon metabolic process

Gpt2

Mm.200423

162.21

821.3

2.34

2-oxoglutarate metabolic process

Chka

Mm.225505

53.81

283.2

2.396

phosphatidylethanolamine biosynthetic process

Sema7a

Mm.335187

58.44

359.47

2.621

inflammatory response

Prl2c2

Mm.88796

203.29

1292.84

2.669

sprouting angiogenesis

Sdf2l1

Mm.30222

188.2

1213.98

2.689

endoplasmic reticulum-stress inducible-gene

Ptgs2

Mm.292547

166.34

1287.09

2.952

prostaglandin biosynthetic process

Atf3

Mm.2706

61.28

546.52

3.157

gluconeogenesis

Chac1

Mm.35083

73.02

659.22

3.174

apoptotic process

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