Table 3 Quantitative comparison of metabolites found in plasma of T2DM-CHD patients and healthy controls.

From: Identification of metabolic biomarkers in patients with type 2 diabetic coronary heart diseases based on metabolomic approach

Metabolites

HMDB

Chemical Shift

Interal in HC groupa (mean ± std) × 10−2

Interal in T2DM- CHD groupa (mean ± std) × 10−2

rb (T2DM-CHD vs HC) (|r|> = 0.532)

VIP

pc (T2DM-CHD vs HC) (p < 0.05)

VLDL/LDL

—

0.87(m), 1.27(m)

23.26 ± 4.11

26.0 ± 6.27

0.176(↑)

0.84

0.135

isoleucine

HMDB00172

0.93(t), 0.99(d)

7.42 ± 0.81

6.57 ± 1.01

0.487(↓)

1.45

0.008

valine

HMDB00883

0.98(d), 1.03(d)

15.8 ± 3.52

13.39 ± 3.35

0.506(↓)

1.47

0.007

isopropanol

HMDB00863

1.16(d)

12.03 ± 6.77

1.63 ± 0.67

0.72(↓)

2.86

0.001

alanine

HMDB00161

1.47(d)

45.06 ± 8.74

30.20 ± 10.45

0.671(↓)

2.15

0.001

leucine

HMDB00687

0.95(m), 1.70(m)

1.18 ± 0.42

0.79 ± 0.33

0.556(↓)

1.69

0.002

arginine

HMDB00517

1.90(m), 3.24(t), 3.76(t)

2.36 ± 0.41

1.52 ± 0.58

0.604(↓)

2.24

0.001

acetate

HMDB00042

1.92(s)

13.37 ± 3.7

9.64 ± 5.24

0.34(↓)

1.30

0.019

proline

HMDB00162

2.03(m), 2.36(m), 3.43(m)

6.43 ± 0.81

4.71 ± 1.61

0.583(↓)

1.87

0.001

glutamine

HMDB00641

2.14(m), 2.46(m), 3.79(m)

3.62 ± 0.62

2.49 ± 0.92

0.548(↓)

2.01

0.001

creatine

HMDB00064

3.02(s), 3.92(s)

13.46 ± 3.88

9.76 ± 3.53

0.407(↓)

1.62

0.003

creatinine

HMDB00562

3.03(s), 4.05(s)

19.92 ± 4.38

15.10 ± 4.06

0.51(↓)

1.79

0.001

glucose

HMDB00122

3.24(m), 4.64(d), 5.23(d)

20.0 ± 5.99

28.32 ± 7.83

0.536(↑)

1.78

0.001

glycine

HMDB00123

3.55(s)

52.79 ± 11.87

32.55 ± 7.75

0.72(↓)

2.64

0.001

threonine

HMDB00167

1.31(d), 3.58(d), 4.25(m)

4.35 ± 1.03

3.00 ± 0.88

0.630(↓)

2.10

0.001

tyrosine

HMDB00158

6.89(m), 7.18(m)

2.66 ± 0.47

2.03 ± 0.45

0.588(↓)

2.03

0.001

3-methylhistidine

HMDB00479

7.00(s), 7.66(s)

5.35 ± 1.55

3.62 ± 1.37

0.55(↓)

1.85

0.001

  1. The arrows (↑/↓) were used to show the metabolite levels increase/decreased compared with healthy controls.
  2. aThe relative integrals of metabolites were determined from 1D 1H NMR analysis of plasma of each group.
  3. bThe values of correlation number extracted from the correlation plots of OPLS-DA models.
  4. cThe p values were obtained from student’s t-test. The chemical shifts in boldface were that we used in calculating integrals and p values.
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