Figure 1: Chemical structures of example IL-17A inhibitors used in this study.
From: Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
Compound 1: example of a lead IL-17A antagonist with a linear peptide motif. Compounds 2 and 3: macrocyclic IL-17A antagonists designed on basis of the structure of compound 1 complexed with IL-17A.
