Figure 2: Characterization of the central binding pocket of the IL-17A dimer (surface presentation with the two polypeptide chains colored in ice blue and gold, respectively) probed using the VISM algorithm (red balls represent the probes used).
From: Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
The high druggability of the pocket is manifested by the large hydrophobic cavity and the favorable druggability score (∆G) which assesses the optimal binding affinity of the binding site.
