Figure 7: Histological and gene expression analysis of NAC pharmacologic therapy in the KC bladder. | Scientific Reports

Figure 7: Histological and gene expression analysis of NAC pharmacologic therapy in the KC bladder.

From: Mesenchymal stem cells protect against the tissue fibrosis of ketamine-induced cystitis in rat bladder

Figure 7

(a–c) Histological analysis of fibrosis (a), TGF-β activation (b), mast-cell infiltration and apoptosis (c) in the bladder tissues of the indicated groups. All quantitative data were normalized to those of the sham group and are presented as dot plot with the mean ± SEM. n = 7, *p < 0.05, **p < 0.01, ***p < 0.001 compared with the KC group with Bonferroni post-test. The representative photomicrographs of the above staining results are shown in Supplementary Figs S3 and S4. (d,e) RQ-PCR analysis of inflammation (d) and fibrosis (e)-related genes in the indicated bladder tissues. Expression is presented as % Gapdh and shown as dot plot with the mean ± SEM (n = 5; *p < 0.05, **p < 0.01, ***p < 0.001 compared with the KC group). ns = non-significant.

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