Figure 4

Marked differences in the relative abundance of gut bacterial genera in the different diet and treatment groups. Effect of (A,B) resveratrol or (C,D) rapamycin on the relative abundance of 7 or 10 bacterial genera, and hierarchical clustering analysis of these bacterial profiles based on the Manhattan distance, were examined in NCD- and HFD-fed mice. Data are expressed as the mean ± SEM (n = 5 per groups). F- and p-values are from two-way ANOVA after Bonferroni’s post hoc test (Supplementary Table S2). ^*P < 0.05 and ^**P < 0.005 compared with NCD-CT. ^#P < 0.05 and ^##P < 0.005 compared with HFD-CT.