Figure 8: Microglial activation in seed-injected mice brain.
From: Exposure to bacterial endotoxin generates a distinct strain of α-synuclein fibril

Microglia activation were analyzed by immunohistochemical analysis 6 months after injection. Immunoreactivity against Iba-1 was analyzed in ipsilateral striatum of the brains (n = 5 per group). (a) Representative images of ipsilateral striatum. (b,c) Optical density of Iba-1 immunoreactivity (b) and percentage of Iba-1-positive area (c). Data show mean ± s.e.m., **p < 0.01 and *p < 0.05, one-way ANOVA, scale bar, 25 μm.