Figure 1

Differences and characterizations in circRNA expression profiles between bladder carcinoma tissues and adjacent non-carcinoma tissues.

(A) Scatter plots are used to evaluate the difference in the expression of circRNAs between experiment group and control group. The values plotted on X and Y axes are the averaged normalized signal values of each group (log2 scaled). The middle green line refers to no difference between the two groups. And the flank green lines represent 2.0 fold changes. The circRNAs above the top green line and below the bottom green line indicate more than 2.0 fold changes between two groups. (B) Volcano plots are using for visualizing differential expression between two different conditions. The vertical lines correspond to 2.0 fold (log2 scaled) up and down, respectively and the horizontal line represents a P-value of 0.05 (−log10 scaled). The red points in plot represent the differentially expressed circRNAs with statistical significance. (C) The distribution of differentially expressed circRNAs in human chromosomes. (D) The bar diagram shows the circRNA category. Most of differentially expressed circRNAs originate from the exons. Some are from introns, while, a few are other sources.