Figure 6

Function annotations for target genes mediated by circTCF25-miR-103a-3p/miR-107 axes.

(A) The bioinformatical prediction of circTCF25 target genes related to Pathways in cancer. The total of 16 nodes and 16 edges are constructed based on base-pairing interactions. (B,C) DAVID function annotation for the miR-103a-3p and miR-107 targeted genes of Pathways in cancer. The vertical axis shows the annotated functions of the target genes. The horizontal axes shows −log2 transformed P-value and the gene number of each cluster respectively. Only the most significantly enriched clusters are included. Details are in Supplementary Table S2. (D) The scatter plots demonstrate all cluster features about P-value and gene count and the plots on the top right corner represent high significance and more genes. Positive regulation of cell proliferation and migration are labeled with high significance and more genes. (E) Mapping of Pathways in cancer mediated by miR-103a-3p and miR-107. In this map, circRNAs could act as positive regulators of target genes, while miRNAs function as negative regulators. These yellow target genes could be regulated by circTCF25-miR-103a-3p/miR-107 axes to devote to the initiation and progression of bladder cancer.